HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Piperidine, 4-(1,1-dimethylethyl)- → 4-[4-(tert-Butyl)piperidin-1-yl]-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Piperidine, 4-(1,1-dimethylethyl)- | HCID 74661 | — |
| Edukt | 4-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407942 | — |
| Produkt | 4-[4-(tert-Butyl)piperidin-1-yl]-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile | HCID 135994991 | — |
Reaktionsschritte
In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 536 mg (3.80 mmol) of 4-tert-butylpiperidine to give 57 mg (42% of theory) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08088769B2 |
| Quelldatensatz | uspto-grants-2012_01 |
| ORD ID | ord-cbfe5ed99dbd4ccb873ed01a5a53db2b |
| Quellennotiz | uspto-grants-2012_01 |