HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Acetylbenzoic Acid → 4-[1-(6-Acetyl-benzo [1,3] dioxol-5-ylamino)-ethyl]-N-(2-amino-phenyl)-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Acetylbenzoic Acid | HCID 11470 | — |
| Edukt | 1-(6-Amino-1,3-benzodioxol-5-yl)ethan-1-one | HCID 120000 | — |
| Edukt | N-(2-Amino-phenyl)-4-[(4-methanesulfonyl-phenylamino)-methyl]-benzamide | HCID 66622022 | — |
| Produkt | 4-[1-(6-Acetyl-benzo [1,3] dioxol-5-ylamino)-ethyl]-N-(2-amino-phenyl)-benzamide | HCID 58930544 | — |
Reaktionsschritte
Title compound 240 was prepared using the same procedures as described for the compound 212a, example 99 (scheme 42, table 1), starting from 1-(6-amino-benzo[1,3]dioxol-5-yl)-ethanone and 4-acetylbenzoic acid (scheme 51). 1H NMR: (DMSO-d6) δ(ppm): 8.69 (s, 1H), 7.03 (d, J=7.8 Hz, 2H), 6.64 (d, J=7.8 Hz, 2H), 6.29 (dd, J=8.3, 7.8 Hz, 1H), 6.09 (t, J=7.8, 7.3 Hz, 1H), 5.90 (d, J=7.8, 1H), 5.72 (d, J=6.8 Hz, 1H), 5.70 (s, 1H), 5.16 (d, J=8.8 Hz, 1H), 4.88 (s, 1H), 4.84 (s, 1H), 4.07 (bd, 1H), 2.30 (s, 3H), 0.62 (d, J=6.83, 3H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08088805B2 |
| Quelldatensatz | uspto-grants-2012_01 |
| ORD ID | ord-cf0b36dbc65a4824ac1bd614b7f4d1af |
| Quellennotiz | uspto-grants-2012_01 |