HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one → 4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one | HCID 5825354 | — |
| Edukt | (E)-1-[2-(Boc-Amino-)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one | HCID 58930506 | — |
| Edukt | 4-[(4-Pyrazin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acid | HCID 66622167 | — |
| Produkt | 4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid | HCID 58930474 | 18% |
Reaktionsschritte
Following the procedure described for the synthesis of the acid 25a (scheme 6, step 3) but substituting enamino ketone 23a for the enamino ketone 338, title compound was obtained in 18% yield and was used for the next steps without further purification. MS (m/z): 441.50 (calc) 442.3 (MH+) (found).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08088805B2 |
| Quelldatensatz | uspto-grants-2012_01 |
| ORD ID | ord-aeeadea4a66a45d79c56970b509663a4 |
| Quellennotiz | uspto-grants-2012_01 |