p-Toluenesulfonic acid → 4-(2-Acetyl-3-oxo-1-butenyl)benzonitrile

Beteiligte Stoffe

Reaktionsschritte

A solution of 4-cyanobenzonitrile (20 g, 0.15 mol), 2,4-pentanedione (17 g, 0.17 mol), piperidine (130 mg, 1.5 mmol) and p-toluene sulfonic acid (260 mg, 1.5 mmol) in toluene (400 ml) is refluxed overnight with a Dean-Stark trap. The solution is concentrated in vacuo and purified over silica gel with cyclohexane/ethyl acetate mixtures as eluent.

Herkunft & Nachweise