HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 428457Erstellt: 24. Oktober 2026
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → 7-[2-(t-Butoxycarbonyl)-8-(methoxyimino)-2,6-diazaspiro[3,4]oct-6-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid
https://huagongshe.com/de/reaction/428457
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 11055142 | — |
| Edukt | 2,6-Diazaspiro[3.4]octane-2-carboxylic acid, 8-(methoxyimino)-, 1,1-dimethylethyl ester | HCID 54547656 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 7-[2-(t-Butoxycarbonyl)-8-(methoxyimino)-2,6-diazaspiro[3,4]oct-6-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid | HCID 54207349 | 93,9% |
Reaktionsschritte
400 mg of 1-cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid and 84 g of t-butyl 8-(methoxyimino)-2,6diazaspiro[3,4]octane-2-carboxylate were added to 10 ml of acetonitrile and the resulting mixture was stirred for 3 hours at 45-50° C. Then the precipitated solid was filtered and dried to give 650 mg of the titled compound(yield: 93.9%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06313299B1 |
|---|
| Quelldatensatz | uspto-grants-2001_11 |
|---|
| ORD ID | ord-78001507230648308ed5a5488c921ec5 |
|---|
| Quellennotiz | uspto-grants-2001_11 |
|---|
