Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | MeOH tetrahydrofuran | HCID 21899815 | — |
| Edukt | 8-(4-Methylthiophen-3-yl)-quinoxaline-5-carboxylic acid | HCID 66914550 | — |
| Edukt | HCID 178480844 | HCID 178480844 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | HCID 178431882 | HCID 178431882 | — |
Reaktionsschritte
The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for 16 h at 60° C., using 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3, Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and 8-(4-methylthiophen-3-yl)-quinoxaline-5-carboxylic acid (Example 67) in Step 14.1. Title compound: ESI-MS: 448.0 [M+H]+; tR=3.00 min (System 1); TLC: Rf=0.14 (DCM/MeOH, 9:1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08536175B2 |
|---|
| Quelldatensatz | uspto-grants-2013_09 |
|---|
| ORD ID | ord-3421b637912e46d1aeccae0efc2b9fbd |
|---|
| Quellennotiz | uspto-grants-2013_09 |
|---|
