3-Methoxyphenol → alpha-Hydroxy-beta-(3-Methoxyphenoxy)-N-(1-Methylethyl)Benzenepropanamide

Beteiligte Stoffe

Reaktionsschritte

This compound was prepared from N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide (10.3 g.), m-methoxyphenol (6.2 g.), sodium hydride (50% oil dispersion, 2.4 g.), 18-crown-6 (1.5 g.) and acetonitrile (500 ml.) as described in Example 12. The crude product (m.p. 118°-120°, yield 2.6 g.) was then recrystallized from ether with a small amount of tetrahydrofuran, giving 2.3 g. of the pure product, m.p. 132°-133°.

Herkunft & Nachweise