HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Edukt | N-tert-Butoxycarbonyl-L-tryptophan | HCID 83169 | — |
| Edukt | L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- | HCID 90234 | — |
| Edukt | BOC-D-alanine | HCID 637606 | — |
| Edukt | Boc-D-Tyr(Bzl)-Oh | HCID 6992575 | — |
| Produkt | Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester | HCID 54340573 | — |
Reaktionsschritte
Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine resin is obtained according to the procedure of Example 1 by treating 20 g. of Nα-t-butoxycarbonyl-D-alanine resin, 0.0132 mol, with 7.4 g., 0.02 mol, of Nα-t-butoxycarbonyl-O-benzyl-D-tyrosine and 4.1 g., 0.02 mol, of dicyclohexylcarbodiimide, (2) 6.0 g., 0.02 mol, of Nα-t-butoxycarbonyl-O-benzyl-L-serine and 4.1 g. of dicyclohexylcarbodiimide, and (3) 6.1 g. of Nα-t-butoxycarbonyl-L-tryptophan and 4.1 g. of dicyclohexylcarbodiimide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04031069 |
| Quelldatensatz | uspto-grants-1977_06 |
| ORD ID | ord-a241e9b4db8e44bd8139d5072b78c7cf |
| Quellennotiz | uspto-grants-1977_06 |