HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Edukt | N-tert-Butoxycarbonyl-L-tryptophan | HCID 83169 | — |
| Edukt | L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- | HCID 90234 | — |
| Edukt | O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosine | HCID 98763 | — |
| Edukt | (2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid | HCID 637605 | — |
| Produkt | Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine | HCID 53678011 | — |
Reaktionsschritte
Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine resin is prepared according to the procedure of Example 1 from Nα-t-butoxycarbonyl-D-valine resin, 11 g., 5 mmol, reacted successively with (1) 3.5 g., 9.4 mmol, of Nα-t-butoxycarbonyl-O-benzyl-L-tyrosine and 2 g., 9.7 mmol, of dicyclohexylcarbodiimide, (2) 3 g., 9.8 mmol, of Nα-t-butoxycarbonyl-O-benzyl-L-serine and 2 g. of dicyclohexylcarbodiimide and (3) 3 g., 9.85 mmol, of Nα-t-butoxycarbonyl-L-tryptophan and 2 g. of dicyclohexylcarbodiimide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04031069 |
| Quelldatensatz | uspto-grants-1977_06 |
| ORD ID | ord-1a651dfc146d4c0fa3cec0dec8da3974 |
| Quellennotiz | uspto-grants-1977_06 |