HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 445148Erstellt: 24. Oktober 2026
Isopropyl iodide → 2-Isopropylamino-4,5-dimethoxy-benzonitrile
https://huagongshe.com/de/reaction/445148
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Isopropyl iodide | HCID 6362 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2-Amino-4,5-dimethoxybenzonitrile | HCID 735967 | — |
| Katalysator | Copper | HCID 23978 | — |
| Produkt | 2-Isopropylamino-4,5-dimethoxy-benzonitrile | HCID 60112825 | — |
Reaktionsschritte
A suspension of 4.52 g (25.4 mmol) 2-amino-4,5-dimethoxy-benzonitrile, 4.38 g (31.7 mmol) potassium carbonate and 100 mg copper powder in 15 ml 2-iodo-propane is stirred at 90° C. for 5 days. Extractive work-up with ethyl acetate/water and concentration i.V. affords a dark oil, which is purified by flash chromatography (ethyl acetate/hexane). yield: 4.15 g (74%) yellow oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08476286B2 |
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| Quelldatensatz | uspto-grants-2013_07 |
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| ORD ID | ord-55a58d2306c7437e944ba3e9a8eac496 |
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| Quellennotiz | uspto-grants-2013_07 |
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