HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 44610Erstellt: 24. Oktober 2026
Azanium;hydrate → 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
https://huagongshe.com/de/reaction/44610
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Azanium;hydrate | HCID 22024077 | — |
| Edukt | ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate | HCID 44232943 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | HCID 44235652 | 54% |
Reaktionsschritte
1.0 g (2.6 mmol) of ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate were dissolved in a mixture of 100 mL of methanol and 100 mL of ammonium hydrate 33%. The solution was stirred in a close bottle at 60° C. for 4 hours. The resulting precipitate was collected giving 0.5 g (54% yield) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08541429B2 |
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| Quelldatensatz | uspto-grants-2013_09 |
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| ORD ID | ord-6b4bb62a093749f2af071cd03ebe2fc4 |
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| Quellennotiz | uspto-grants-2013_09 |
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