1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene → 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene	HCID 12621549	—
Edukt	5-(2-Benzylaminopropoxy)salicylamide	HCID 13754334	—
Lösungsmittel	Isopropanol	HCID 3776	—
Produkt	1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol	HCID 13754335	—

Reaktionsschritte

A solution of 10.2 g of 1-(2,3-epoxypropoxy)-4-(2-methoxyethoxy)benzene and 11.0 g of 5-[2-(benzylamino)propoxy]salicylamide in 200 ml of isopropanol is refluxed for 24 hours. By concentration of the solution by evaporation, crude 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]propan-2-ol is obtained as an oil which is used in its crude state for debenzylation.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04727067
Quelldatensatz	uspto-grants-1988_02
ORD ID	ord-828bade31618484ebf88db104605db75
Quellennotiz	uspto-grants-1988_02