HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 5-(2,3,5,6-Tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| Edukt | 5-Amino-2-(trifluoromethoxy)benzoic acid | HCID 11830994 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 5-(2,3,5,6-Tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid | HCID 10049466 | 81% |
Reaktionsschritte
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-trifluoromethoxybenzoic acid (1.35 g, 6.23 mmole), DMF (50 ml), TEA (6 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.10 ml, 6.73 mmole), 2.25 g (81.0% yield) of 5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid was obtained as a yellow solid.:
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07189878B2 |
| Quelldatensatz | uspto-grants-2007_03 |
| ORD ID | ord-3ee3301dd9694704b236c3789af9fe89 |
| Quellennotiz | uspto-grants-2007_03 |