HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,1'-Carbonyldiimidazole → 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Edukt | N-Benzylaminodiacetic acid | HCID 77606 | — |
| Edukt | 5-Aminoindole | HCID 78867 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione | HCID 22931025 | — |
Reaktionsschritte
N-Benzyliminodiacetic acid was reacted with CDI and 5-aminoindole in THF to obtain 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione, which was then reacted with lithium aluminum hydride in THF. Conc. hydrochloric acid and palladium hydroxide were added to an ethanol solution of thus obtained compound and the whole was reacted under a hydrogen atmosphere of 3 atm for 65 hours to obtain an objective compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07196080B2 |
| Quelldatensatz | uspto-grants-2007_03 |
| ORD ID | ord-b6dd4d4e1f0746f5a86b715e167a3784 |
| Quellennotiz | uspto-grants-2007_03 |