Acetyl chloride → 4-(Piperidin-4-yloxy)benzonitrile hydrochloride

https://huagongshe.com/de/reaction/459925

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Acetyl chloride	HCID 6367	—
Edukt	tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate	HCID 23019443	—
Lösungsmittel	Methanol	HCID 887	—
Produkt	4-(Piperidin-4-yloxy)benzonitrile hydrochloride	HCID 17832273	96%

Reaktionsbedingungen

Temperatur	0 °C

Reaktionsschritte

Add dropwise acetyl chloride (2.5 mL) to methanol (5.0 mL) at 0° C. Stir the resulting solution at 0° C. for 90 min. Then add a solution of 4-(4-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (284 mg, 0.94 mmol) in methanol. Stir the resulting mixture for 3 h. Evaporate the solvent and triturate with diethyl ether to provide the title compound (216 mg, 96%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07196100B2
Quelldatensatz	uspto-grants-2007_03
ORD ID	ord-494f68581f2d484bbc465e010094f0fe
Quellennotiz	uspto-grants-2007_03