HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 460015Erstellt: 24. Oktober 2026
Carbon tetrabromide → 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
https://huagongshe.com/de/reaction/460015
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Carbon tetrabromide | HCID 11205 | — |
| Edukt | Triphenylphosphine | HCID 11776 | — |
| Edukt | (4-Methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methanol | HCID 2783005 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Cyclohexane | HCID 8078 | — |
| Produkt | 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole | HCID 2794629 | — |
Reaktionsschritte
To a solution of {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol (intermediate 1, 0.9 g) in dry dichloromethane (30 ml) stirring at 0° C. was added carbon tetrabromide (1.1 g) and triphenylphosphine (0.995 g). The reaction was stirred at 0° C. for 1 hour, diluted with cyclohexane (30 ml) and purified by SPE cartridge (Si cartridge using chloroform:cyclohexane (1:1) to give the title compound as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07196107B2 |
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| Quelldatensatz | uspto-grants-2007_03 |
|---|
| ORD ID | ord-462655ef133b43e0badbf023b32817be |
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| Quellennotiz | uspto-grants-2007_03 |
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