HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Iodo-4-(trifluoromethyl)phenol → N-(2,4-dimethoxybenzyl)-2,5-difluoro-4-[2-iodo-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Iodo-4-(trifluoromethyl)phenol | HCID 11572816 | — |
| Edukt | N-(2,4-Dimethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide | HCID 59436583 | — |
| Produkt | N-(2,4-dimethoxybenzyl)-2,5-difluoro-4-[2-iodo-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide | HCID 59436549 | 67% |
Reaktionsschritte
Prepared according to Preparation 255 using N-(2,4-dimethoxybenzyl)-2,4,5-trifluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 647, 1000 mg, 2.26 mmol) and 2-iodo-4-(trifluoromethyl)phenol (Preparation 224, 975 mg, 3.38 mmol) to afford the title compound, 1080 mg, 67% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08541588B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-ad20caa0087446038f0a4f57bc2ca7b0 |
| Quellennotiz | uspto-grants-2013_09 |