Pyridine → 4-(Methylsulfonamido)benzoic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To 215.2 g (2.72 mole) of pyridine in 1250 ml of dichloromethane is added 238 g (1.44 mole) of ethyl 4-aminobenzoate. After cooling to 0° C., a solution of 177.6 g (1.55 mole) of methanesulfonyl chloride in 250 ml of dichloromethane is added with stirring. Upon completion of the addition, the ice bath is removed and the reaction is stirred for one hour at room temperature.

Herkunft & Nachweise