HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Floxuridine → 2'-deoxy-5-fluoro-3'-O-(1-naphthylmethyl)-uridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Floxuridine | HCID 5790 | — |
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 1-(Bromomethyl)naphthalene | HCID 137844 | — |
| Produkt | 2'-deoxy-5-fluoro-3'-O-(1-naphthylmethyl)-uridine | HCID 14074406 | 18% |
Reaktionsschritte
The general procedures of Reference Examples 4 and 5 were followed using 1.3 g of potassium hydroxide, 1.00 g of 2'-deoxy-5-fluorouridine and 2.7 g of 1-naphthylmethyl bromide, thereby producing 0.28 g of the title compound in a yield of 18%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05155113 |
| Quelldatensatz | uspto-grants-1992_10 |
| ORD ID | ord-d6c8084ee8ec40b2a2eb6cbd64127813 |
| Quellennotiz | uspto-grants-1992_10 |