HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Methoxy-2-methylpropan-1-amine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-methoxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Methoxy-2-methylpropan-1-amine | HCID 11789141 | — |
| Edukt | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098928 | — |
| Produkt | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-methoxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide | HCID 58548393 | 71% |
Reaktionsschritte
According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 2-methoxy-2-methylpropan-1-amine, providing the title compound as yellow solid (71%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08623866B2 |
| Quelldatensatz | uspto-grants-2014_01 |
| ORD ID | ord-9ea9d7d233a44b46a7253bcb86f601df |
| Quellennotiz | uspto-grants-2014_01 |