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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 469092Erstellt: 24. Oktober 2026

Trimethylaluminum → N-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-oxadiazole-2-carboxamide

https://huagongshe.com/de/reaction/469092

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTrimethylaluminumHCID 16682925—
Edukt2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N-methylethanamineHCID 67217191—
EduktMethyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylateHCID 67217606—
LösungsmittelDichloromethaneHCID 6344—
ProduktN-{2-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-N-methyl-1,3,4-oxadiazole-2-carboxamideHCID 58393293—

Reaktionsschritte

The title compound was prepared according to general procedure AT using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate (50 mg, 0.135 mmol), 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N-methylethanamine (110 mg, 0.54 mmol) and trimethylaluminium (2 M in toluene, 0.27 mL) in DCM (10 mL). A portion of the crude product was purified using prep method A, then prep method B.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08623859B2
Quelldatensatzuspto-grants-2014_01
ORD IDord-8e68a9486f4b40bbb363d11558e12187
Quellennotizuspto-grants-2014_01