HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-[(1-Methylpiperidin-3-yl)methyl]piperazine → Ammonia
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-[(1-Methylpiperidin-3-yl)methyl]piperazine | HCID 2736940 | — |
| Edukt | Trimethylaluminum | HCID 16682925 | — |
| Edukt | Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate | HCID 67217606 | — |
| Lösungsmittel | 1,2-Dichloroethane | HCID 11 | — |
| Produkt | Ammonia | HCID 222 | — |
| Produkt | HCID 46176070 | HCID 46176070 | — |
Reaktionsschritte
The title compound was prepared according to general procedure AT using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate (30 mg, 0.08 mmol), 1-[(1-methylpiperidin-3-yl)methyl]piperazine (31 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08623859B2 |
| Quelldatensatz | uspto-grants-2014_01 |
| ORD ID | ord-5f575b8bf1424c28b0151939205d7d72 |
| Quellennotiz | uspto-grants-2014_01 |