HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diphenyl Ether → Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diphenyl Ether | HCID 7583 | — |
| Edukt | diethyl N-(3-oxo-1-cyclohexen-1-yl)-aminomethylenemalonate | HCID 12877078 | — |
| Lösungsmittel | Hexane | HCID 8058 | — |
| Produkt | Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | HCID 12876362 | 722,7% |
Reaktionsschritte
A mixture of 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (2.8 g, 1 mmol) and diphenylether (20 mL) was refluxed for 15 min. After cooling, n-hexane (80 mL) was added. The resulting solid was isolated via filtration and recrystallized from methanol to give 4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (1.7 g 72%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08629162B2 |
| Quelldatensatz | uspto-grants-2014_01 |
| ORD ID | ord-4fb86b2c00d34012b69db31741222f57 |
| Quellennotiz | uspto-grants-2014_01 |