2-(Pyridin-3-yl)ethan-1-amine → [8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(2-pyridin-3-yl-ethyl)-amine

Beteiligte Stoffe

Reaktionsschritte

[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(2-pyridin-3-yl-ethyl)-amine was prepared from 2-chloro-8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine (250 mg, 0.81 mmol) and 2-pyridin-3-yl-ethylamine (0.95 mL, 8.1 mmol) in a manner analogous to Example 406. Product isolated as a light yellow powder (98.5 mg, 31%). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 8.71 (d, J=6.4 Hz, 1H), 8.51 (m, 1H), 8.39 (d, J=7.8 Hz, 2H), 8.03 (d, J=7.4 Hz, 2H), 7.86 (d, J=7.4 Hz, 1H), 7.70 (t, J=15.1, 7.6 Hz, 1H), 7.30 (m, 1H), 7.22 (m, 1H), 7.04 (t, J=13.9, 7.3 Hz, 1H), 6.86 (m, 1H), 3.62 (m, 2H), 3.28 (s, 3H), 3.06 (m, 2H). MS=394 (MH)+.

Herkunft & Nachweise