HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,4-Bis(trifluoromethyl)benzaldehyde → (7bR,11aS)-N-[2,4-bis(trifluoromethyl)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,4-Bis(trifluoromethyl)benzaldehyde | HCID 2736095 | — |
| Edukt | Tert-butyl (7br,11as)-6-amino-1,2,7b,10,11,11a-hexahydro-4h-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8h)carboxylate | HCID 86586438 | — |
| Produkt | (7bR,11aS)-N-[2,4-bis(trifluoromethyl)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine | HCID 60071804 | — |
Reaktionsschritte
Using 2,4-bis(trifluoromethyl)benzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 129. LRMS (ES)+: 472.4 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06699852B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-a99601a3f01b48718ec216c36a11f79c |
| Quellennotiz | uspto-grants-2004_03 |