HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(2S)-3-Phenylpropane-1,2-diamine → 2-(((S)-2-Amino-3-phenylpropyl)-amino)-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (2S)-3-Phenylpropane-1,2-diamine | HCID 12699301 | — |
| Edukt | 2-Chloro-3-methyl-6-pyridin-4-yl-5-m-tolyl-3H-pyrimidin-4-one | HCID 16115688 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 2-(((S)-2-Amino-3-phenylpropyl)-amino)-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone hydrochloride | HCID 57515702 | — |
Reaktionsschritte
A solution of 2-chloro-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone (3.34 g, 10.71 mmol) and (S)-1-benzyl-1,2-ethanediamine (2.3 g, 15.31 mmol) in ethanol (50 ml) was stirred at room temperature for 16 h. The solvent was evaporated and the crude product recrystallized from methanol. MS (m/z): 426 (M+H)+; C26H27N5O requir. 425.5 (free base).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06649604B2 |
| Quelldatensatz | uspto-grants-2003_11 |
| ORD ID | ord-b5f203d05e464a108205e18daca099b8 |
| Quellennotiz | uspto-grants-2003_11 |