HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 484154Erstellt: 24. Oktober 2026
Sodium Iodide → 3-(4-(1-(1,1-dioxo-1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one
https://huagongshe.com/de/reaction/484154
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Iodide | HCID 5238 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-(Piperazin-1-yl)-1,2-benzothiazole-1,1-dione | HCID 695718 | — |
| Edukt | 3-(4-Bromobutyl)-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10708747 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 3-(4-(1-(1,1-dioxo-1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10576037 | 52,2% |
Reaktionsschritte
A mixture of 3-(4-bromobutyl)-1-thia-3-azaspiro[4.4]-nonan-4-one (3.50 g), 1-(1,1-dioxo-1,2-benzisothiazol-3-yl)piperazine (3.30 g), K2CO3 (4.98 g) and NaI (280 mg) in acetonitrile (230 ml) was heated at 85° C. for 20 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.89 g of needles, m.p. 137°-140° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US05229388 |
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| Quelldatensatz | uspto-grants-1993_07 |
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| ORD ID | ord-7e46a4a07a724fd7a89f5b8c6ed1389c |
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| Quellennotiz | uspto-grants-1993_07 |
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