Zurück
HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 48423Erstellt: 24. Oktober 2026

Triethylamine → 4-(5-Phenoxyindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine

https://huagongshe.com/de/reaction/48423

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTriethylamineHCID 8471—
Edukt4-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 290225—
Edukt2-Amino-5-phenoxyindan hydrochlorideHCID 22719615—
LösungsmittelEthanolHCID 702—
Produkt4-(5-Phenoxyindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidineHCID 1209406739,4%

Reaktionsschritte

Using 2-amino-5-phenoxyindan hydrochloride (99 mg, 0.36 mmol), ethanol (3 ml), triethylamine (92 μl, 0.66 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (61 mg, 0.33 mmol), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to obtain the title compound (51 mg, 0.13 mmol) having the following physical properties:

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06703421B1
Quelldatensatzuspto-grants-2004_03
ORD IDord-8387294f106c4f7bb651daf0cbb0ac2c
Quellennotizuspto-grants-2004_03