HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 4-(5-Phenoxyindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 4-Chloro-5-methylthieno[2,3-d]pyrimidine | HCID 290225 | — |
| Edukt | 2-Amino-5-phenoxyindan hydrochloride | HCID 22719615 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 4-(5-Phenoxyindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine | HCID 12094067 | 39,4% |
Reaktionsschritte
Using 2-amino-5-phenoxyindan hydrochloride (99 mg, 0.36 mmol), ethanol (3 ml), triethylamine (92 μl, 0.66 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (61 mg, 0.33 mmol), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to obtain the title compound (51 mg, 0.13 mmol) having the following physical properties:
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06703421B1 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-8387294f106c4f7bb651daf0cbb0ac2c |
| Quellennotiz | uspto-grants-2004_03 |