Benzoyl chloride → (S)-3-(Benzoylaminomethyl)-5-methylhexanoic acid

Beteiligte Stoffe

Reaktionsschritte

Benzoyl chloride (0.88 ml, 7.6 mmol) was added to a stirred suspension of pregabalin (1.0 g, 6.3 mmol) in THF (80 ml) at room temperature under argon and the reaction mixture was stirred for 18 hours. The reaction mixture was then filtered and concentrated in vacuo. The residue was chromatographed (SiO2, heptane-ethyl acetate, 1:1 to 3:7) to give 4 (0.78 g, 47%).

Herkunft & Nachweise