HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(1S)-2-amino-1-phenylethan-1-ol → 1-Ethyl-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (1S)-2-amino-1-phenylethan-1-ol | HCID 643217 | — |
| Edukt | 1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | HCID 11281295 | — |
| Edukt | 1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid | HCID 53487829 | — |
| Produkt | 1-Ethyl-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | HCID 57675168 | — |
Reaktionsschritte
Intermediate 48 was prepared from Intermediate 17 and (1S)-2-amino-1-phenylethanol (commercially available from Fluka) using an analogous method to that for Intermediate 42. LCMS showed MH+=410; TRET=2.62 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07528148B2 |
| Quelldatensatz | uspto-grants-2009_05 |
| ORD ID | ord-d7b92bef333c496aa76ac118660837a8 |
| Quellennotiz | uspto-grants-2009_05 |