HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Bromoacetonitrile | HCID 11534 | — |
| Edukt | 4-(Naphth-1-yl)piperidine hydrobromide | HCID 19096220 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride | HCID 19784336 | 91,83% |
Reaktionsschritte
5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05242933 |
| Quelldatensatz | uspto-grants-1993_09 |
| ORD ID | ord-c23b7acaed9b4fbbb249c32c51607fe4 |
| Quellennotiz | uspto-grants-1993_09 |