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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 498484Erstellt: 24. Oktober 2026

(2-Amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → (5-Cyclopropyl-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

https://huagongshe.com/de/reaction/498484

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt(2-Amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl esterHCID 69489287—
Edukt3-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl esterHCID 69489307—
Produkt(5-Cyclopropyl-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl esterHCID 86589449—

Reaktionsschritte

The title compound was prepared (2-amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J39) (289 mg, 0.914 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (284 mg, 0.914 mmol) according to the general procedure M. Obtained as a yellow foam (368 mg, 73%).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06949542B2
Quelldatensatzuspto-grants-2005_09
ORD IDord-620d5c9d1aa54da0a539bcf332991524
Quellennotizuspto-grants-2005_09