HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Chloroaniline → 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Chloroaniline | HCID 7932 | — |
| Edukt | 7-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine | HCID 22741951 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride | HCID 22742013 | — |
Reaktionsschritte
By analogy with Example 25, 300 mg (0.96 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)-phthalazine is reacted in 3.9 ml 1-butanol with 302 μl (2.88 mmol) 3-chloroaniline. Suspension of the raw product in 1 ml boiling ethanol and filtration lead to the title compound: HPLC: tRet(Grad5-40)=11.3; FAB MS (M+H)+=404.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06710047B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-9e2ce66826cc481a866d58559b881a2a |
| Quellennotiz | uspto-grants-2004_03 |