HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,4-Butane sultone → 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,4-Butane sultone | HCID 15411 | — |
| Edukt | Sulfolane | HCID 31347 | — |
| Edukt | 2,3-Dimethyl-3-(4-sulfobutyl)-3H-indole-5-sulfonic acid | HCID 59366226 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole | HCID 86646192 | 86,8% |
Reaktionsbedingungen
| Temperatur | 140 °C |
|---|
Reaktionsschritte
To 2,3-dimethyl-3-(4-sulfobutyl)-5-sulfo-3H-indole (10 g) was added butane sultone (30 g) and the mixture heated to 140° C. overnight. On cooling to room temperature, sulfolan (20 ml) was added and the mixture poured into diethyl ether (500 ml). The resultant precipitate was removed by filtration and dried to give the desired product (12 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07767829B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-967fe06e8ce64cbea94cfa6f6fa5c726 |
| Quellennotiz | uspto-grants-2010_08 |