HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Quinoxaline-6-carbonyl chloride → HCID 86612084, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Quinoxaline-6-carbonyl chloride | HCID 2776328 | — |
| Edukt | tert-butyl N-[4-(cyclopropylsulfonylcarbamoyl)-18-hydroxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl]carbamate | HCID 68797769 | — |
| Produkt | HCID 86612084 | HCID 86612084 | 38% |
Reaktionsschritte
Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.176 mmol) and 6-quinoxalinecarbonyl chloride (68 mg, 0.35 mmol). The final trituration (diethyl ether/hexane) and filtration gave 48 mg (38%) of 18-(6-quinoxalinecarbonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diazatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 98.5% pure (HPLC), MS m/z 723 (M−H)−, HRMS: calcd. 725.2969 and found 725.2947 (M+H)+, mp 158-160° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07772183B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-12bd5710626f4ed0a793b938c46576f0 |
| Quellennotiz | uspto-grants-2010_08 |