HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Pyridinemethanamine → (S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Pyridinemethanamine | HCID 19509 | — |
| Edukt | (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate | HCID 86722018 | — |
| Produkt | (S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722030 | — |
Reaktionsschritte
Same procedure as described in preparation 133a was used from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (374 mg, 0.96 mmols) and pyridine-2-ylmethanamine (0.30 ml, 2.87 mmols). After reverse phase chromatography the title compound was obtained (74 mg, 17%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09340547B2 |
| Quelldatensatz | uspto-grants-2016_05 |
| ORD ID | ord-7924540c81e04da7a4c919b93d5390ce |
| Quellennotiz | uspto-grants-2016_05 |