Cyclohexylamine → 9-Bromo-5-cyclohexylcarbamoylmethyl-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione

Beteiligte Stoffe

Reaktionsschritte

A procedure similar to that described in Example 5 was carried out with 9-bromo-5-carboxymethyl-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (150 mg, 0.442 mmol) and cyclohexylamine (50 mg, 0.51 mmol) to give 160 mg of the title compound (86%): mp>270° C.; 1H NMR (270 MHz, DMSO-d6) δ12.04 bs, 1H), 7.86 (d, 1H, J=7.6 Hz), 7.21 (s, 1H), 7.15 (s, 1H), 5.03~5.18 (m, 1H), 3.43~3.60 (m, 1H), 3.03 (ddd, 1H, J=17.1, 13.5, 4.5 Hz), 2.76 (dm, 1H, J=17.1 Hz), 2.36 (dd, 1H, J=16.2, 4.5 Hz), 2.28 (dd, 1H, J=16.2, 11.7 Hz), 1.98 (dm, 1H, J=13.5 Hz), 1.50~1.86 (m, 5H), 1.03~1.36 (m, 6H).

Herkunft & Nachweise