HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
M-Phenylenediamine → N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | M-Phenylenediamine | HCID 7935 | — |
| Edukt | 2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine | HCID 22060451 | — |
| Produkt | N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine | HCID 22060474 | — |
Reaktionsschritte
In like manner to the preparation of N4-(3-aminophenyl)-N2-[2-(methoxycarbonyl)-benzofurane-5-yl]-5-fluoro-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 1,3-diaminobenzene were reacted to give N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 11.89 min.; purity: 97.6%; MS (m/e): 312.05 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09346765B2 |
| Quelldatensatz | uspto-grants-2016_05 |
| ORD ID | ord-e5b297cf6a324df4b763e16f8d5650a0 |
| Quellennotiz | uspto-grants-2016_05 |