HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Pentanamine → 4-(1-Ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Pentanamine | HCID 12019 | — |
| Edukt | 3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester | HCID 304557 | — |
| Produkt | 4-(1-Ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester | HCID 67250481 | — |
Reaktionsschritte
4-Chloro-8-methoxy-quinoline-3-carboxylic acid ethyl ester (250 mg, 0.94 mmol) was treated with 1-ethyl-propylamine following general procedure B to afford 4-(1-ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester (240 mg). Thus obtained amino-ester was hydrolyzed to the corresponding acid in quantitative yield using general procedure D and then transformed into the corresponding ethylamide (160 mg) following general procedure E.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08853226B2 |
| Quelldatensatz | uspto-grants-2014_10 |
| ORD ID | ord-ca15a98e065d4585bc9410fe15920a46 |
| Quellennotiz | uspto-grants-2014_10 |