HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trimethylsilylacetylene → Methyl 5-((trimethylsilyl)ethynyl)nicotinate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trimethylsilylacetylene | HCID 66111 | — |
| Edukt | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Produkt | Methyl 5-((trimethylsilyl)ethynyl)nicotinate | HCID 53821751 | 13,6% |
Reaktionsschritte
Under the conditions of example 21 B, 5 g of 5-bromonicotinic acid methyl ester is reacted with 2.43 g of trimethylsilylacetylene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 734 mg of 5-(2-trimethlsilylethinyl)-nicotinic acid methyl ester is obtained as oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05624943 |
| Quelldatensatz | uspto-grants-1997_04 |
| ORD ID | ord-b32f6a6c03b1401f8f6ebe00916729cb |
| Quellennotiz | uspto-grants-1997_04 |