HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 4-Methyl-5-phenyl-1-(3-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 15-Crown-5 | HCID 36336 | — |
| Edukt | Thiophene-3-sulfonyl Chloride | HCID 2776378 | — |
| Edukt | 4-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 71362812 | — |
| Produkt | 4-Methyl-5-phenyl-1-(3-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde | HCID 86232716 | 88% |
Reaktionsschritte
Using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 60 mg), 15-crown-5 (0.30 mL) and (3-thienyl)sulfonyl chloride (237 mg), a procedure as in Reference Example 219 was performed to give the title compound as a solid (yield 290 mg, 88%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048909B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-882b43de2c2c45cb874b041085cf2c2c |
| Quellennotiz | uspto-grants-2011_11 |