HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pentafluorobenzyl bromide → HCID 59383141, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pentafluorobenzyl bromide | HCID 74484 | — |
| Edukt | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Produkt | HCID 59383141 | HCID 59383141 | 89,7% |
Reaktionsschritte
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and 2,3,4,5,6-pentafluorobenzyl bromide (26.6 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(2,3,4,5,6-pentafluorobenzyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (41.9 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08053465B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-8c1b1bdf78cd42f384105cb04523b0bd |
| Quellennotiz | uspto-grants-2011_11 |