HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetonitrile → Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetonitrile | HCID 6342 | — |
| Edukt | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Edukt | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| Produkt | Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate | HCID 66980031 | — |
Reaktionsschritte
Ethyl piperidine-4-carboxylate (100 mg) was treated with 2-chloro-6-methoxyquinoline (Intermediate 1) (90 mg) in MeCN (0.8 mL) and TEA (100 mg) in a sealed tube at 180° C. for 6 h in a microwave reactor. After aqueous work-up with EtOAc and column purification, eluting with EtOAc/hexane, ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate (90 mg) was afforded as a solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09433618B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-550c1e91025842e7bcb55db1293d04a9 |
| Quellennotiz | uspto-grants-2016_09 |