HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 559052Erstellt: 24. Oktober 2026
Diisopropylethylamine → 2-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide
https://huagongshe.com/de/reaction/559052
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
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| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | (1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protected | HCID 1514389 | — |
| Edukt | 2-(1H-benzo[d][1,2,3]triazol-1-yloxy)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide | HCID 57472013 | — |
| Produkt | 2-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide | HCID 57472011 | 22,1% |
Reaktionsschritte
To a solid of 2-(1H-benzo[d][1,2,3]triazol-1-yloxy)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide (100 mg, 0.25 mmol) in vial was added tert butyl (1S,2R)-2-aminocyclohexylcarbamate (0.3 M solution in NMP, 1.25 mL, 0.375 mmol) and DIPEA (0.09 mL, 0.5 mmol). It was heated at 80° C. for 2 h, cooled and purified by preparative HPLC to give 2-((1R,2S)-2-aminocyclohexylamino)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide (21 mg). MS found for C20H25N7O as (M+H)+ 380.4. UV: λ=219.2, 241.6, 336.7.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08063058B2 |
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| Quelldatensatz | uspto-grants-2011_11 |
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| ORD ID | ord-760807b865b94cdcb9655d9085641dd3 |
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| Quellennotiz | uspto-grants-2011_11 |
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