HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 559585Erstellt: 24. Oktober 2026
8-Hydroxyquinoline → 5-chloro-N-((1-(4-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide
https://huagongshe.com/de/reaction/559585
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 8-Hydroxyquinoline | HCID 1923 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-Methyluracil | HCID 79066 | — |
| Edukt | 5-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide | HCID 24986897 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | 5-chloro-N-((1-(4-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide | HCID 24760161 | 22,6% |
Reaktionsschritte
A mixture of 5-chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide 1-6 (66 mg, 0.15 mmol), 3-methyluracil (60 mg, 0.48 mmol), 8-hydroxyquinoline (10 mg, 0.069 mmol) and K2CO3 (60 mg, 0.43 mmol) in DMSO (1 mL) was degassed with Ar before being charged with CuI (15 mg, 0.079 mmol). The mixture in a sealed tube was heated at 130° C. overnight. The mixture was then purified by HPLC to give the titled compound (15 mg). MS 442.2 and 444.2 (M+H, Cl pattern).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08063077B2 |
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| Quelldatensatz | uspto-grants-2011_11 |
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| ORD ID | ord-f6632a6f1a684812871b6bebd0e33e71 |
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| Quellennotiz | uspto-grants-2011_11 |
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