4-Morpholinebutanenitrile → 4-(Morpholin-4-yl)butan-1-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To anhydrous THF (70 mL) was added LiAlH4 (5.37 g, 142 mmol) in one portion. The mixture was stirred at 0° C. for 20 min, and a solution of 4-morpholinobutanenitrile (7.26 g, 47 mmol) in anhydrous THF (40 mL) was added dropwise. Upon the end of addition the mixture was refluxed for 4 h, then cooled to 0° C., diluted with water (20 mL) and filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

Herkunft & Nachweise