HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 56669Erstellt: 24. Oktober 2026
Sodium hydride → Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate
https://huagongshe.com/de/reaction/56669
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | Lithium Bromide | HCID 82050 | — |
| Edukt | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Edukt | Ethyl 2-bromo-3-phenylpropanoate | HCID 4737529 | — |
| Produkt | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate | HCID 117622558 | — |
Reaktionsschritte
544 mg (3.13 mmol) of 4-bromopyridin-2(1H)-one and 845 mg (3.3 mmol) of ethyl 2-bromo-3-phenylpropanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. for 1.5 h). Yield: 572 mg (51% of theory)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US09434690B2 |
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| Quelldatensatz | uspto-grants-2016_09 |
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| ORD ID | ord-2da1cfbee0a04af5a39d8083688e43f8 |
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| Quellennotiz | uspto-grants-2016_09 |
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