HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → 5-(3-Methoxyphenyl)-1-phenyl-4-(p-toluenesulfonyloxymethyl)pyrrolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | o-Toluenesulfonyl chloride | HCID 8623 | — |
| Edukt | 4-Hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one | HCID 13362003 | — |
| Produkt | 5-(3-Methoxyphenyl)-1-phenyl-4-(p-toluenesulfonyloxymethyl)pyrrolidin-2-one | HCID 13362004 | — |
Reaktionsschritte
To 17.2 gm. of 4-hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one in 35 ml. of dry pyridine was added at 5°-10°12.2 gm of p toluenesulfonyl chloride over one hour. Workup of the reaction following the procedure given in example 1E provided 17.6 gm of product as a crude oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04731457 |
| Quelldatensatz | uspto-grants-1988_03 |
| ORD ID | ord-68903cfabe854f82b62f3e74f0905063 |
| Quellennotiz | uspto-grants-1988_03 |