4-Methylmorpholine → HCID 72714674, Verbindung

Beteiligte Stoffe

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Reaktionsschritte

A mixture of 1-[6-fluoro-4-(oxetan-3-yl)-2-pyridyl]-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridine (0.1443 mmol; 63 mg), tert-butyl N-[(3S)-3-piperidyl]carbamate (0.4329 mmol, 80.7 mg), and N-Methylmorpholine (0.3607 mmol; 36.9 mg; 0.0401 mL) in 1-Methyl-2-pyrrolidinone (3 mL) in a sealed pressure vial was heated at 100° C. overnight. The mixture was cooled to room temperature. The solvents were removed. The residue was treated with 20% TFA in DCM at room temperature for 2 h. The mixture was concentrated and the residue was purified by reverse phase HPLC to afford 250 as an off-white solid (17.5 mg, 26%). 1H NMR (400 MHz, DMSO) δ 9.61-9.57 (s, 1H), 9.49-9.43 (s, 1H), 9.36-9.29 (s, 1H), 8.69-8.66 (s, 1H), 8.65-8.61 (s, 1H), 7.33-7.30 (s, 1H), 6.82-6.76 (s, 1H), 5.02-4.95 (m, 2H), 4.73-4.66 (t, J=6.3 Hz, 2H), 4.42-4.35 (d, J=13.2 Hz, 1H), 4.35-4.27 (dd, J=15.0, 7.2 Hz, 1H), 4.20-4.13 (d, J=10.7 Hz, 1H), 3.29-3.21 (m, 2H), 3.08-3.01 (m, 1H), 2.98-2.91 (s, 1H), 2.66-2.61 (s, 3H), 2.01-1.83 (m, 3H), 1.71-1.58 (d, J=13.4 Hz, 1H), 1.51-1.40 (d, J=10.8 Hz, 1H), 0.99-0.92 (t, J=7.3 Hz, 1H); MS (ESI) m/z: 443.2 [M+H]+

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