1-Methylpiperazine → 1-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine

Beteiligte Stoffe

Reaktionsschritte

A solution of 3-bromo-6-chloro-2-methylpyridine (700 mg, 3.39 mmol) and 1-methylpiperazine (0.753 mL, 6.78 mmol) in DMF (4 mL) was heated in microwave reactor at 150° C. for 50 minutes. The mixture was subsequently purified via preparative HPLC, eluting with a gradient of 10-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.

Herkunft & Nachweise